The Applied Organic Chemistry Group


Publications & Reprints

33.Solvent from forestry biomass. Pinane a stable terpene derived from pine tree byproducts to substitute n-hexane for the extraction of bioactive compounds”.

Yara-Varón, A. Selka, A. S. Fabiano-Tixier, M. Balcells, R. Canela-Garayoa, Antoine Bily, M. Touaibiac and F. Chemat.

Green Chemistry. (2016). First published on line October 4, 2016

doi: 10.1039/c6gc02191c


32. “Orthogonal Synthesis of Xeno Nucleic Acids”

Guillaume Fiers, Dalila Chouikhi, Laurence Oswald, Abdelaziz Al Ouahabi, Delphine Chan-Seng, Laurence Charles, and Jean-François Lutz.

Chem. Eur. J., 22 ,1–5 (2016)

doi : 10.1002/chem.201604386


31. “Synthesis, Characterization, and Catechol Oxidase Activity of Cu (II) Complexes Derived from New Imidazolidine Derivatized Ligands”.

Louhibi, N. Merad-Boussalah, I. Belfilali, L. Boukli-Hacene, C. Ziani-Cherif, S. El Kadiri, and R. Touzani

Proceeding of 2015 2nd Int’l Conference on Advances in Chemical, Biological & Environmental Engineering (ACBEE-2015). ISBN 978-93-84422-49-3


30. “Synthesis of Well-Defined Polystyrene Rink Amide Soluble Supports and Their Use in Peptide Synthesis”

Meryem Imane Amrane , Dalila Chouikhi , Nezha Badi , Jean-François Lutz

Macromol. Chem. Phys. 215(20), p1984-1990 (2014)

doi: 10.1002/macp.201400347


29. “Out of Africa. Algeria is an unknown hotbed of chemistry. "

Andrew Warmington & Chewki Ziani-Cherif.

Specialty Chemicals Magazine. Feb 2013 Online Issue.


28. «A serendipitous conversion of enaminolactone nitriles with primary amines: a new synthesis of substituted 2-aminopyridine derivatives»

Nawel Cheikh, Didier Villemin, Nathalie Bar, Jean-Francois Lohier, Nourredine Choukchou-Braham, Bachir Mostefa-Kara, Jana Sopkova

Tetrahedron 69, 1234-1247 (2013)



27. «Two versatile routes towards Cerpegin and analogues: applications of a one pot reaction to new analogues of Cerpegin»

Didier Villemin, Nawel Cheikh, Liang Liao, Nathalie Bar, Jean-Francois Lohier, Jana Sopkova,

Noureddine Choukchou-Braham, Bachir Mostefa-Kara »

Tetrahedron 68, 4906-4918 (2012)



26. «5,6-Dihydro-2H-pyranones and 5,6-dihydro-2H-pyridones and their derivatives modulate in vitro human T lymphocyte function»

Baba Hamed, A. Medjdoub, B. Mostefa Kara, H. Merzouk, D. Villemin, M. Narce

Mol Cell Biochem  360 : 23–33 (2012)

doi: 10.1007/s11010-011-1040-x


25. «Efficient synthesis of new butenolides by subsequent reactions: application forthe synthesis of original iminolactones, bis-iminolactones and bis-lactones»

Nawel Cheikh, Nathalie Bar, Nourredine Choukchou-Braham, Bachir Mostefa-Kara, Jean-François Lohier, Jana Sopkova, Didier Villemin

Tetrahedron 67, 1540-1551 (2011)



24. “Chemical Composition and Antifungal Activity of Aleppo Pine Essential Oil”

Abi-Ayad M., Abi-Ayad F.Z., Lazzouni H.A., Rebiahi S.A., Ziani-Cherif C., Bessiere

Journal of Medicinal Plants Research vol. 5(22), pp.5433-5436, (2011).


23. «Nouvelle voie de synthèse des 2-Aminopyridines»

Zahira Kibou, Nawel Cheikh, Noureddine Choukchou-Braham, Bachir Mostefa-Kara, Mohammed Benabdellah, Didier Villemin

Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry 12 (2), pp. 121–126 (2011)


22. «Polyethylene glycol (PEG 300) and water-ethanol as benign solvent systems for the synthesis of new of 2-hydroxynaphthalen-1(4H)-ones»

Villemin, M Benabdellah, N. Choukchou-Braham and B. Mostefa-Kara

Synthetic Communications, 40 (20) : 3109-3118 (2010)      

doi: 10.1080/00397911003797916


21. «A Green Route for Synthesis of New 1, 2-Naphthoquinomethane acetonitriles in Water»

Villemin, M Benabdellah, M.N. Rahmoun, N. Choukchou-Braham and B. Mostefa-Kara

Synthetic Communications, 40 (23) : 3514-3521 (2010)      

doi: 10.1080/00397910903457340


20. “Antimicrobial Screening of the Algerian Lawsonia Inermis (henna)”

M.N.Rahmoun, M.Benabdallah, D. Villemin, K.Boucherit, B.Mostefa-Kara, C.Ziani-Cherif and N.Choukchou-Braham

Der Pharma Chemica, Vol2, No.6, pp320-326 (2010)


19. “New Chemical Tools for the assessment of Hemolytic Anemia Induced by Naphtoquinones”

Mostefa-Kara, C. Ziani-Cherif, M. Benabdallah, N.M. Rahmoun, D. Villemin, N. Choukchou-Braham and K. Boucherit

Der Pharma Chemica,Vol 2, No.1, pp 14-21 (2010)


18. “Theoretical Study of the Inhibition of β-Secretase.”

I.Abdelli, S.Sari, C.Ziani-Cherif and S.Ghalem

Asian Journal of Chemistry, Vol 19, No.7, pp5407-5416 (2007)


17. «Prediction of the reactivity of 2(5H)-furanones as potential dienophiles in Diels-Alder reactions using philicity indexes»

Benmeddah, S.M. Mekelleche, W. Benchouk, B. Mostefa-kara, D. Villemin.

Journal of Molecular Structure: THEOCHEM 821, p42–46 (2007)



16. "Base-promoted Reactions in Ionic Liquid Solvent: Synthesis of Butenolides."

Didier Villemin, Bachir Mostefa-Kara, Nathalie Bar, Noureddine Choukchou-Braham, Nawel Cheikh, Amel Benmeddah, Hassan Hazimeh and Chewki Ziani-Cherif.

Letters in Organic Chemistry, vol 3: (7), pp558-559 (2006)

doi: 10.2174/157017806778341807


15. "Gamma-Secretase as a Pharmacological Target in Alzheimer Disease Research. When, Why and How ? "

Chewki Ziani-Cherif, Bachir Mostefa-Kara, Fatima Z. Brixi-Gormat.

Current Pharmaceutical Design, vol 12 : (33), pp4313-4335 (2006)

doi: 10.2174/138161206778792994


14. «Solvent-free reaction on KF-alumina under microwave : serendipitous one-pot domino synthesis of new isobenzofuran-1(3H)-ones from alpha-hydroxyketones»

Villemin, N. Cheikh, B. Mostefa-Kara, N. Bar, N. Choukchou-Braham and M.A. Didi

Tetrahedron Letters, 47, 31 : 5519-5521 (2006)


13. «Synthèse Cascade en milieu basique de Lactones. Application à la synthèse de la Cerpegine et d’Isobenzofuranones»

Villemin, L. Liao, N. Bar, N. Cheikh, B. Mostefa-Kara, N. Choukchou-Braham and M.A. Didi

Scientific Study & Research, Vol II(4) : 885-891 (2006)


12. «A Case of Pictet-Spengler Revisited : Application to the Synthesis of Dihydroisocoumarin»

Choukchou-Braham, B. Mostefa-Kara, N. Cheikh, M.A. Didi and D. Villemin

Synthetic Communications, 35(2) : 169-178 (2005)



11. "Peptide-based, irreversible inhibitors of gamma-secretase activity."

Siân C. Piper, Zareen Amtul, Laura Galiñanes-Garcia, Victor G. Howard, Chewki Ziani-Cherif, Chris McLendon, Marjorie J.  Rochette, Abdul Fauq, Todd E. Golde, M. Paul. Murphy.

Biochemical and Biophysical Research Communications, vol 305, pp529-533 (2003)



10. “[4 + 3] Cycloaddition of aminoallylcations with 1,3-dienes: 11-oxatricyclo[ 11-Oxatricyclo[]undec-3-en-10-one,(1α,2β,5β,6α)-]”

Jonghoon Oh, Chewki Ziani-Cherif, Jong-Ryoo Choi, and Jin Kun Cha

Organic Syntheses, Coll. Vol. 10, p.584 (2004); Vol. 78, p.212 (2002).

doi: 10.15227/orgsyn.078.0212


9. “A novel Gamma Secretase assay Based on detection of the Putative C-Terminal Fragment-Gamma Of APP”

Inga Pinnix, Usha Musunuru, Han Tan, Arati Skidharan, Todd E. Golde, Christopher Eckman, Chewki Ziani-Cherif, Luisa Onstead, Kumar Sambamurti

Journal of Biological Chemistry, vol 276: (1), pp481-487 (2001).



8. “Cell Free Assays For g-Secretase Activity”

Chris. McLendon, TianPei Xin, Chewki Ziani-cherif, M. P. Murphy, Kirk A. Findlay, Patrick A. Lewis, Inga Pinnix, Kumar Sambamurti, Rong Wang, Abdul Fauq, Todd E. Golde

FASEB Journal, vol 14, pp 2383-2386 (2000)



7. “Peptide nucleic acids targeted to angiotensinogen lower mRNA levels, blood pressure and angiotensin I levels in rats”

Tyler-McMahon,B.M., Stewart,J.A., Jansen,K., Ziani-Cherif,C., Fauq,A., E.Richelson

Journal of Clinical Pharmacology. vol 40, p1048 (2000)


6. “Molecular Targets for the inhibition of Aβ production”

Chris McLendon, Paul Murphy, Chewki Ziani-Cherif, Abdul Fauq, Todd E Golde

Neurobiology of Aging, Vol21, Suppl.1, p180 (May-June 2000)

doi: http://dx.doi.org/10.1016/S0197-4580(00)82147-8


5. “Synthesis of (S)- and (R)- enantiomers of p-(4-Hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites “

Abdul H. Fauq, Chewki Ziani-Cherif and Elliott Richelson

Tetrahedron Asymmetry. vol 9, pp 2333-2338 (1998)



4. “New [4+3] Cycloaddition Approach to Cis-2,8-Disubstituted Oxocanes “

Heejin Kim, Chewki Ziani-Cherif, Jonhoon Oh and Jin Kun Cha

Org. Chem. vol 60, pp792-793 (1995)

doi: 10.1021/jo00109a005


3. “Total Synthesis of Natural Gingerols, the Three Active Principles of Ginger “

Guy Solladie, Chewki Ziani-Cherif

Org. Chem. vol. 58, pp2181-2185 (1993).

doi: 10.1021/jo00060a038


2. “Total Synthesis of (-)-(R)-Yashabushiketol. “

Guy Solladie, Chewki Ziani-Cherif, Francis Jesser.

Tetrahedron Letters, Vol 33, pp931-934 (1992).



1. “Asymmetric Synthesis of C-1-C-8 Fragment of Leukotriene B4 and C-11-C-20 Fragments of Leukotriene B4 and 12(S)-hydroxy-5,8, 14(E) Eicosatetraenoic Acid.”

Guy Solladie, Chafiq Hamdouchi, Chewki Ziani-Cherif.

Tetrahedron Asymmetry. vol 2, No.6, pp457-469 (1991).



Group Members




BENZERDJEB Salima, Teaching Assistant

FEROUANI Ghaniya, Graduate student

SELKA Ayyoub, Graduate student

KHETTAR Ibrahim, Graduate Student



Chewki Ziani-Cherif

The Blog


Tel: (213) 554 81 40 16

email: c_zianicherif@mail.univ-tlemcen.dz