Bioactive Heterocycles





Publications & Reprints

23. Zahira Kibou, Nawel Cheikh, Didier Villemin, Noureddine Choukchou-Braham, « A rapid synthesis of highly functionalized 2-pyridones and 2-aminopyridines via a microwave-assisted multicomponent reaction », Mater. Environ. Sci., 7, 3061-3067, 2016.


22. Zahira Kibou, Nawel Cheikh, Noureddine Choukchou-Braham, Didier Villemin, Jean-François Lohier, « Easy Solventless Synthesis of new mono and bis amino-5H-chromeno[3,4-c]pyridin-5-one derivatives », Tetrahedron, 72, 1653-1661, 2016.


21. Fatima Belhadj, Zahira Kibou, Nawel Cheikh, Noureddine Choukchou-Braham, Didier Villemin; « Convenient access to new aminopyrido[2,3-d]pyrimidines derivatives»; Tetrahedron Letters, 56, 5999-6002, 2015.


20. Amina Berrichi, Redouane Bachir, Mohammed Benabdallah, Noureddine Choukchou-Braham; « Convenient Supported nano gold catalyzed three-component coupling reactions of amines, dichloromethane and terminal alkynes (AHA) », Tetrahedron Letters, 56, 1302-1306, 2015.


19. Didier Villemin, Zahira Belhadj, Nawel Cheikh, Noureddine Choukchou-Braham, Nathalie Bar, Jean-Francois Lohier; « Solventless Convenient Synthesis of New Cyano-2-Aminopyridines Derivatives from Enaminonitriles», Tetrahedron Letters, 54, 1664-1668, 2013.


18. Nawel Cheikh, Didier Villemin, Nathalie Bar, Jean-Francois Lohier, Nourredine Choukchou-Braham, Bachir Mostefa-Kara, Jana Sopkova; « A serendipitous conversion of enamino-lactone nitriles with primary amines: a new synthesis of substituted 2-aminopyridine derivatives », Tetrahedron, 69, 1234-124, 2013.


17. Nadjib Rahmoun, Zahia Boucherit-Otmani, Kebir Boucherit, Mohammed Benabdallah, Noureddine Choukchou-Braham, « Antifungal activity of the Algerian Lawsoniainermis (henna) », Pharmaceutical Biology, 51, 131–135, 2013.


16. Nadjib Mohammed Rahmoun, Zahia Boucherit-Atmani, Mohammed Benabdallah, Kebir Boucherit, Didier Villemin, Noureddine Choukchou-Braham « Antimicrobial activities of the henna extract and some synthetic naphthoquinones derivatives », American Journal of Medical and Biological Research, 1, 16-22, 2013.


15. Didier Villemin, Nawel Cheikh, Liang Liao, Nathalie Bar, Jean-Francois Lohier, Jana Sopkova, Noureddine Choukchou-Braham, Bachir Mostefa-Kara « Two versatile routes towards Cerpegin and analogues: applications of a one pot reaction to new analogues of Cerpegin »; Tetrahedron, 68, 4906-4918, 2012.


14. M. Rahmoun, Z. Boucherit-Otmani, K. Boucherit, M. Benabdallah, D. Villemin, N. Choukchou-Braham « Antibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives »; Médecine et maladies infectieuses, 42, 270–275, 2012.


13. Cheikh, N. Bar, N. Choukchou Braham, B. Mostefa-Kara, J.-F. Lohier, J. Sopkova and D. Villemin, « Efficient synthesis of new butenolides by subsequent reactions: application for the synthesis of original iminolactones, bis-iminolactones and bis-lactones», Tetrahedron, 47, 1540-1551, 2011.

12. Kibou, N. Cheikh, N. Choukchou Braham, B. Mostefa-Kara, M. Benabdallah, D. Villemin, « Nouvelle voie de Synthèse des 2-Aminopyridines», Scientific Study & Research, 12(2), 121-126, 2011.

11. Kibou, N. Cheikh, N. Choukchou Braham, B. Mostefa-Kara, M. Benabdallah, D. Villemin, A Simple and Efficient Procedure for a 2-Pyridones Synthesis under Solvent- Free Conditions International Journal of Organic Chemistry. 1, 242-249, 2011.

10. Kibou, N. Cheikh, N. Choukchou Braham, B. Mostefa-Kara, M. Benabdallah, D. Villemin, New methodology for the synthesis of 2-pyridones using basic Al2O3 as catalyst J. Mater. Environ. Sci. 2, 293-298, 2011.

9. Mostefa-Kara, C. Ziani-Cherif, M. Benabdallah, N. M. Rahmoun, D. Villemin, N. Choukchou-Braham, K. Boucherit., « New chemical tools for the assessment of homolyticanemia induced by », Der Pharma Chemica, 2(6), 14-21, 2010.

8. Villemin, M. Benabdellah, N. Rahmoun, C. Jouannic, N. Choukchou-Braham, B. Mostefa-Kara, « A green route for synthesis of new 1,2-naphthoquinomethane acetonitriles in water »,Synthetic Communications, 40(23), 3514-3521, 2010.

7. Villemin, M. Benabdellah, N. Choukchou-Braham, B. Mostefa-Kara, « Polyethylene glycol (PEG300) and water-ethanol as benign solvent systems for the synthesis of a novel series of 2-hydroxynaphthalen-1(4H)-ones», Synthetic Communications, 40(20), 1532-2432, 2010.

6. Mostefa-Kara, C. Ziani-Cherif, M. Benabdallah, N. M. Rahmoun, D. Villemin, N. Choukchou-Braham and K. Boucherit., « New chemical tools for the assessment of homolyticanemia induced by naphthoquinones », Der Pharma Chemica, 2(1), 14-21, 2010.

5. Villemin, L. Liang, N. Bar, N. Cheikh, B. Mostefa-Kara, N. Choukchou Braham, M. A. Didi, « Synthèse cascade en milieu basique de lactones. Application à la synthèse de la Cerpégine et d’Isobenzofuranones  », Scientific Study & Research, VII (4), 885-892, 2006.

4. Villemin, B. Mostefa-Kara, N. Bar, N. Choukchou-Braham, N. Cheikh, A. Benmeddah, H. Hazimeh and C. Ziani-Cherif. « Base promoted in ionic liquid solvent: Synthesis of Butenolides », Letters in Organic Chemistry, 3, 558-559, 2006.

3. Villemin, N. Cheikh, B. Mostefa-Kara, N. Bar, N. Choukchou Braham and M. A. Didi « Solvent-free reaction on KF-alumina under microwave : serendipitous one-pot domino synthesis of new isobenzofuran-1(3H)-ones from alpha-hydroxyketones », Tetrahedron Letters, 47, 5519-5521,  2006.

2. Choukchou Braham, B. Mostefa-Kara, N. Cheikh, M. A. Didi and D. Villemin « A case of pictet-Spengler revisited: Application to the synthesis of Dihydro-isocoumarine », Synthetic Communications, 35, 171-180, 2005.

1. Choukchou Braham, Y. Asakawa and J. P. Lepoittevin, « Isolation, structure determination and synthesis of new dihydroisocoumarins from Ginkgo Biloba L. », Tetrahedron Letters, 35, 3949-3952, 1994.


Group Members


 CHOUKCHOU-BRAHAM Noureddine  Professor, Team Head  
CHEIKH Nawel Professor, U. Béchar
KIBOU Zahira MCA, C.U. Ain Témouchent
BENABDALLAH Mohammed MCB, U. Tlemcen
SARI Lina Public Health Assistant, C.H.U. Tlemcen
DATOUSSAID Yazid MCB, E.S.S.A. Tlemcen
BELHADJ Fatima MAB, U. Oran 1
NOUALI Fatiha Graduate student (4th Y), U.  Tlemcen
BEKRI Sarra Graduate student (4th Y), U.  Tlemcen
MEHIAOUI Nawel Graduate student (1th Y), U.  Tlemcen
TOUATI Youssouf Graduate student (1th Y), U.  Tlemcen



About N. Choukchou-Braham

Noureddine Choukchou-Braham received his PhD in Organic Chemistry from the University of Strasbourg - France in 1995. Since then, he is a research professor at the University of Tlemcen. In 2000, he was a founding member of Laboratory of Catalysis and Synthesis in Organic Chemistry (LCSCO). In 2005, he became team leader of chemical mediators and in March 2016 he held the post of director. In November 2015, he joined the University Business Liaison Office (BLEU) and at the same time is a collaborator of the Vice-Rector in charge of External Relations, Cooperation, Animation and Communication and scientific events.